Twenty Thousand ORFan Microbial Protein Families for the Biologist?
نویسندگان
چکیده
منابع مشابه
Twenty thousand ORFan microbial protein families for the biologist?
The genomes of most newly sequenced organisms contain a significant fraction of ORFs (open reading frames) that match no other sequence in the databases. We refer to these singleton ORFs as sequence ORFans. Because little can be learned about ORFans by homology, the origin and functions of ORFans remain a mystery. However, in this era of full genome sequencing, it seems that ORFans have been un...
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Sir James Spence, whose recent death was such a loss to British medicine, has many memorials in the form of his contributions to knowledge; a significant memorial is that of this account of the "thousand family survey" which he inaugurated and inspired. He guided the book, which is the story of the survey, almost to the point of publication and so, as the authors state, it is a memorial "largel...
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ORFans are open reading frames (ORFs) with no detectable sequence similarity to any other sequence in the databases. Each newly sequenced genome contains a significant number of ORFans. Therefore, ORFans entail interesting evolutionary puzzles. However, little can be learned about them using bioinformatics tools, and their study seems to have been underemphasized. Here we present some of the qu...
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The ability to build accurate protein families is a fundamental operation in bioinformatics that influences comparative analyses, genome annotation, and metabolic modeling. For several years we have been maintaining protein families for all microbial genomes in the PATRIC database (Pathosystems Resource Integration Center, patricbrc.org) in order to drive many of the comparative analysis tools ...
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ژورنال
عنوان ژورنال: Structure
سال: 2003
ISSN: 0969-2126
DOI: 10.1016/s0969-2126(02)00938-3